Publikationen
Terheyden-Keighley D, Leibinger M, Zeitler C and Fischer D (2023)
Transneuronal delivery of cytokines to stimulate mammalian spinal cord regeneration
Methods in Molecular Biology (in press)
Prokosch V, Liu H, Leibinger M and Fischer D (2022)
Regeneration of the optic nerve- how far are we from reality?
Der Ophthalmologe; 119(9):919-928
Terheyden-Keighley D, Hilla AM and Fischer D (2022)
CXCR4 signaling in CNS Regeneration: Friend or Foe?
Neural Regeneration Research; 17(7):1481-1483
Gobrecht P, Gebel J, Hilla A, Gisselmann G, Fischer D (2022)
VASH1/2 inhibition accelerates functional recovery of injured nerves
bioRxiv; 2022.09.20.507918
Hilla AM, Baehr A, Leibinger M, Andreadaki A and Fischer D (2021)
CXCR4/CXCL12 mediated entrapment of axons at the injury site compromises optic nerve regeneration
PNAS; 118(21):e2016409118. doi: 10.1073/pnas.2016409118
Klimas R, Sgodzai M, Motte, Mohamad N, Renk P, Blusch A, Grüter T, Pedreiturria X, Gobrecht P, Fischer D, Schneider-Gold C, Reinacher-Schick A, Tannapfel A, Yoon MS, Gold R, Pitarokoili K (2021)
Dose-dependent immunomodulatory effects of Bortezomib In Experimental Autoimmune Neuritis
Brain Comm; 3(4):fcab238
Terheyden-Keighley D, Leibinger M and Fischer D (2021)
Transneuronal delivery of designer cytokines: Perspectives for spinal cord injury
Neural Regeneration Research; 17(2):338-340
Leibinger M, Zeitler C, Gobrecht P, Gisselmann G, Andreadaki A and Fischer D (2021)
Transneuronal delivery of hyper-IL-6 enables functional recovery after severe spinal cord injury in mice
Nature Comm; 12(1):391. doi: 10.1038/s41467-020-20112-4
Dietrich M, Koska V, Hecker C, Göttle P, Hilla AM, HeskampA, Lepka K, Issberner A, Hallenberger A, Baksmeier C, Steckel J, Balk L, Knier B, Korn T, Havla J, MartÌnez-Lapiscina EH, Sol·N, Manogaran P, Olbert ED, Schippling S, Cruz-Herranz A, Yiu H, Button J, Gonzalez Caldito N, von Gall C, Mausberg AK, Settner M, Zimmerman H, Paul F, Brandt AU, K¸ry P, Goebels N, Aktas O, Berndt C, Saidha S, Green AJ, Calabresi PA, Fischer D, Hartung HP, Albrecht P (2020)
Protective effects of 4-Aminopyridine in experimental optic neuritis and multiple sclerosis
Brain; 143(4):1127-1142. doi: 10.1093/brain/awaa062
Freund RRA, Gobrecht P, Fischer D and Arndt HD (2020)
Advances in chemistry and bioactivity of parthenolide
Nat.Prod.Rep.; 10.1039/c9np00049f
Freund RRA, Gobrecht P, Moser P, Fischer D and Arndt HD (2019)
Synthesis and biological profiling of parthenolide ether analogs
Org. and biomol. Chem; doi: 10.1039/c9ob02166c
Cruz-Herranz A, Dietrich M, Hilla AM, Yiu HH, Levin MH, Hecker C, Issberner A; Hallenberger A, Christian Cordano C, Lehmann-Horn K, Balk LJ, Aktas O, Ingwersen J, von Gall C, Hartung HP, Zamvil SS, Fischer D, Albrecht P, Green AJ (2019)
Monitoring retinal changes with optical coherence tomography predicts neuronal loss in experimental autoimmune encephalomyelitis
Journal of Inflammation, 6(1):203.doi: 10.1186/s12974-019-1583-4.
Freund RRA, Gobrecht P, Rao Z, Schlosser R, Görls H, Werz O, Fischer D and Arndt AD (2019)
Stereoselective total synthesis of parthenolides indicates target selectivity for tubulin carboxypeptidase activity
Chemical Science 10(31):7358-7364
Leibinger M, Hilla A, Andreadaki A and Fischer D (2019)
GSK3/CRMP2 signaling confers PTEN knockout mediated axonal regeneration
Communications Biology 2:318
The Role of Microtubule Detyrosination in Axon Regeneration (2019)
Gobrecht P, Terheyden-Keighley D, Fischer D
Biomedical Journal of Scientific & Technical Research 17 (1), 12447-12449
Human retinal ganglion cell axon regeneration by recapitulating developmental mechanisms: effects of recruitment of the mTOR pathway (2019)
Teotia P, Van Hook MJ , Fischer D, Ahmad I
Development 146 (13), dev178012
The role of muscle LIM protein in the nervous system (2019)
Terheyden-Keighley D, Fischer D
Neural Regeneration Research 14 (11), 1907
Levin E, Leibinger M, Gobrecht P, Hilla AM, Andreadaki A and, Fischer D (2019)
Muscle LIM Protein is expressed in the injured adult CNS and promotes Axon Regeneration
Cell Reports, 26(4):1021-1032.e6
Dietrich M, Hecker C, Hilla A, Cruz-Herranz A, Hartung HP, Fischer D, Green A, Albrecht P (2019)
Using optical coherence tomography and optokinetic response as structural and functional visual system readouts in mice and rats
Journal of Visualized Experiments, J. Vis. Exp. (143), e58571
Gisselmann G, Alisch D, Welbers-Joop B, Hatt H (2018)
Effects of Quinine, Quinidine and Chloroquine on Human Muscle Nicotinic Acetylcholine Receptors.
Front Pharmacol. 9:1339
Hilla A and Fischer D (2018)
Studying the Role of Microglia in Neurodegeneration and Axonal Regeneration in the murine Visual System
Bio-protocol 8(16): e2979
Dietrich M, Helling N, Hilla A, Heskamp A, Issberner A, Hildebrandt T, Kohne Z, Küry P, Berndt C, Aktas O, Fischer D, Hartung HP, Albrecht P (2018)
Early alpha-lipoic acid therapy protects from degeneration of the inner retinal layers and vision loss in an experimental autoimmune encephalomyelitis-optic neuritis model
Journal of Neuroinflammation; 15(1): 71
Fischer D, Harvey AR, Pernet V, Lemmon VP and Park KK (2017)
Optic Nerve Regeneration in Mammals: Regenerated or Spared Axons?
Exp. Neurology; 296:83-88
Leibinger M, Andreadaki A, Golla R, Levin E, Hilla AM, Diekmann H and Fischer D (2017)
Boosting CNS axon regeneration by harnessing antagonistic effects of GSK3 activity
PNAS; 201621225. doi: 10.1073/pnas.1621225114
Hilla AM, Diekmann H and Fischer D (2017)
Microglia are irrelevant for neuronal degeneration and axon regeneration after acute injury
Journal of Neuroscience; 37(25):6113-6124
Levin E, Andreadaki A, Gobrecht P, Bosse F and Fischer D (2017)
Nociceptive DRG neurons express muscle lim protein upon axonal injury
Scientific Reports; 7(1):643
Levin E, Diekmann H and Fischer D (2016)
Highly efficient transduction of primary adult CNS and PNS neurons
Scientific Reports; 6:38928.
Fischer D (2016)
Hyper-IL-6: A potent and efficacious stimulator of RGC regeneration
Eye; 10.1038/eye.2016.234
Diekmann H and Fischer D (2016)
Pathenolide: A novel pharmacological approach to promote nerve regeneration
Neural Regeneration Research; 11(10):1566-1567
Leibinger M, Andreadaki A, Gobrecht P, Levin E, Diekmann H and Fischer D (2016)
Boosting CNS axon regeneration by circumventing limitations of natural cytokine signaling
Molecular Therapy; 10.1038/mt.2016.102.
Gobrecht P, Andreadaki A, Diekmann H, Heskamp A, Leibinger M and Fischer D (2016)
Promotion of functional nerve regeneration by inhibition of microtubule detyrosination
Journal of Neuroscience; 36(14):3890-902
Schmidt T, Fischer D, Andreadaki A, Bartelt-Kirbach B and Golenhofen N (2016)
Induction and phosphorylation of the small heat shock proteins HspB1/Hsp25 and HspB5/aBcrystallin in the rat retina upon optic nerve injury
Cell Stress and Chaperones; 21(1):167-78
Diekmann H and Fischer D (2015)
Role of GSK3 in peripheral nerve regeneration
Neural Regeneration Research; 10(10):1602-3
Diekmann H, Kalbhen P and Fischer D (2015)
Active Mechanistic Target of Rapamycin plays an ancillary rather than essential role in Zebrafish CNS axon regeneration
Front Cell Neuroscience; 9:251
Diekmann H, Kalbhen P and Fischer D (2015)
Characterization of optic nerve regeneration using transgenic zebrafish.
Front Cell Neuroscience; 9: 18
Gobrecht P, Leibinger M, Andreadaki A and Fischer D (2014)
Maintenance of GSK3 activity markedly facilitates peripheral nerve regeneration
Nature Comm; 5: 4561
Levin E, Leibinger M, Andreadaki A, Fischer D (2014)
Neuronal expression of muscle LIM protein in postnatal retinae of rodents.
PLoS One; 9(6): e100756.
Stutzki H, Leibig C, Andreadaki A, Fischer D, Zeck G (2014)
Inflammatory stimulation preserves physiological properties of retinal ganglion cells after optic nerve injury
Front Cell Neuroscience; 8: 38
Leibinger M, Andreadaki A, Diekmann H and Fischer D (2013)
Neuronal STAT3 activation is essential for CNTF and inflammatory stimulation induced CNS axon regeneration
Cell Death Dis; 4: e805
Heiduschka P, Renninger D, Fischer D, Müller A, Hofmeister S, Schraermeyer U (2013)
Lens injury has a protective effect on photoreceptors in the RCS rat
ISRN Ophthalmology, 2013, Article ID 814814
Braunger BM, Pielmeier S, Demmer C, Landstorfer V, Kawall D, Abramov N, Leibinger M, Kleiter I, Fischer D, Jägle H, Tamm ER (2013)
TGF-β Signaling Protects Retinal Neurons from Programmed Cell Death during the Development of the Mammalian Eye.
J Neuroscience; 33(35): 14246-14258
Diekmann H, Leibinger M and Fischer D (2013)
Do growth-stimulated retinal ganglion cell axons find their central targets after optic nerve injury? New insights by three-dimensional imaging of the visual pathway
Exp Neurology; 248: 254-257
Leibinger M, Müller A, Gobrecht P, Diekmann H, Andreadaki A, Fischer D (2013)
Interleukin-6 contributes to CNS axon regeneration upon inflammatory stimulation.
Cell Death Dis; 25; 4: e609.
Heskamp A, Leibinger M, Andreadaki A, Gobrecht P, Diekmann H, Fischer D (2013)
CXCL12/SDF-1 facilitates optic nerve regeneration.
Neurobiol Dis; 55: 76-86
Diekmann H, Fischer D (2013)
Glaucoma and optic nerve repair
Cell Tissue Res; 353(2): 327-337
Fischer D, Leibinger M (2012)
Promoting optic nerve regeneration.
Prog Retin Eye Res; 31(6): 688-701
Fischer D (2012)
Stimulating axonal regeneration of mature retinal ganglion cells and overcoming inhibitory signaling.
Cell Tissue Res; 349(1): 79-85
Leibinger M, Andreadaki A, Fischer D (2012)
Role of mTOR in neuroprotection and axon regeneration after inflammatory stimulation.
Neurobiol Dis; 46(2): 314-24
Sippl C, Bosserhoff AK, Fischer D, Tamm E (2011)
Depletion of optineurin in RGC-5 cells derived from retinal neurons cause apoptosis and reduces the secretion of neurotrophins
Exp Eye Res; 93(5): 669-680
Sengottuvel V and Fischer D (2011)
Facilitating axon regeneration in the injured CNS by microtubules stabilization (2011)
Comm & Integr Biology 4; 4: 391-393
Bischof J, Müller A, Fänder M, Knippschild U and Fischer D (2011)
Neurite outgrowth of mature retinal ganglion cells and PC12 cells requires activity of CK1 delta and epsilon
PloSOne; 6(6): e20857
Sengottuvel V, Leibinger M, Pfreimer M, Andreadaki A, and Fischer D (2011)
Taxol facilitates axon regeneration in the mature CNS
J Neuroscience; 31(7): 2688-2699
Grozdanov V, Müller A, Sengottuvel V, Leibinger M and Fischer D (2010)
A method for preparing primary retinal cell cultures for evaluating the regenerative state of mature CNS neurons
Current Protocols in Neuroscience; Chapter 3: Unit 3.22.
Fischer D (2010)
What are the principal mediators of optic nerve regeneration after inflammatory stimulation in the eye?
Proc Natl Acad Sci; 107(3): E8
Hauk TG, Leibinger M, Müller A, Andreadaki A, Knippschild U, Fischer D (2010)
Intravitreal application of the Toll-like receptor 2 agonist Pam3Cys stimulates axon regeneration in the mature optic nerve.
Invest Ophthalmol Vis Sci; 51(1): 459-464
Fischer D, Kirsch M, Leibinger M, Müller A (2010)
CNTF and LIF are essential key mediators of the beneficial effects of inflammatory stimulation
J Neuroscience; elet. Jan. 11.
Utz A, Hirner H, Baltz A, Hillenbrand A, Schmidt B, Deppert W, Henne-Bruns D, Fischer D, Thal DR, Leithäuser F, and Knippschild U (2010)
Analysis of cell-type specific expression of CK1 epsilon in various tissues of young adult BALB/c mice and in mammary tumors of SV40 T-Ag transgenic mice
J of Histochemistry & Cytochemistry; 58(1): 1-15.
Leibinger M, Müller A, Hauk TG, Andreadaki A, Kirsch M and Fischer D (2009)
Neuroprotective and axon growth promoting effects following inflammatory stimulation on mature retinal ganglion cells in mice depend on CNTF and LIF
J Neuroscience; 29(45): 14334-14341
Müller A, Hauk TG, Leibinger M, Marienfeld RB and Fischer D (2009)
Stimulation of axon regeneration of mature retinal ganglion cells by exogenous CNTF depends on endogenous CNTF expression in retinal astrocytes
Molecular Cell Neuroscience; 41(2): 233-246.
Löhler J, Hirner H, Schmidt B, Kramer K, Fischer D, Thal DR, Leithäuser F, Knippschild U (2009) Immunohistochemical characterisation of cell-type specific expression of CK1delta in various tissues of young adult BALB/c mice
PlosOne; 4(1): e4174
Leidner J, Palkowitsch L, Marienfeld U, Fischer D, Marienfeld RB (2008)
Identification of lysine residues critical for the transcriptional activity and poly-ubiquitination of the NF-kappaB family member RelB
Biochemical Journal; 416(1): 117-27.
Weiss CK, Kohnle MV, Landfester K, Hauk TG, Fischer D, Schmitz-Wienke J,
Mailänder V (2008)
The first step into the brain - uptake of NIO-PBCA nanoparticles by endothelial cells in vitro and in vivo and direct evidence for their blood-brain-barrier permeation
ChemMedChem; 3(9): 1395-1403
Fischer D (2008)
CNTF, a key factor in mediating the beneficial effects of inflammatory reactions in the eye
Brain; 131(6): e97
Fischer D, Hauk TG, Müller A and Thanos S (2008)
Crystallins of the bg-superfamily mimick the effects of lens-injury and promote axon regeneration
Molecular Cell Neuroscience; 37(3): 471-479
Hauk TG, Müller A, Lee J, Schwendener R and Fischer D (2008)
Neuroprotective and axon growth promoting effects of intraocular inflammation do not depend on oncomodulin or the presence of large numbers of activated macrophages
Exp Neurol; 2008 Feb; 209(2): 469-482.
Müller A, Hauk TG and Fischer D (2007)
Astrocyte derived CNTF switches RGCs to a regenerative state following intraocular inflammation
Brain; 130(Pt 12): 3308-3320.
Teuchert M*, Fischer D*, Schwalenstöcker B, Habisch HJ, Böckers TM
and Ludolph AC (2006)
A dynein mutation attenuates motor neuron degeneration in SOD1G93A mice
Exp Neurol; 198(1): 271-274. (* first authors)
Panagis L, Thanos S, Fischer D and Dermon C.R. (2005)
Unilateral optic nerve crush induces bilateral retinal glia cell proliferation
J European Neuroscience; 21(8): 2305-2309.
Heiduschka P, Fischer D, Thanos S (2005)
Recovery of visual evoked potentials after regeneration of cut retinal ganglion cell axons within the ascending visual pathway in adult rats
Restorative Neurology and Neuroscience; 23: 303-312
Fischer D, Petkova V, Thanos S and Benowitz LI (2004)
Switching mature retinal ganglion cells to a robust growth state in vivo: gene expression and synergy with RhoA inactivation
J Neuroscience; 24(40): 8726-8740
Heiduschka P, Fischer D and Thanos S (2004)
Neuroprotection and Regeneration after Traumatic Lesion of the Optic Nerve
Klin Monatsbl Augenheilkunde; 221(8): 684-701
Fischer D, He Z and Benowitz LI (2004)
Counteracting the Nogo receptor enhances optic nerve regeneration if retinal ganglion cells are in an active growth state
J Neuroscience; 24(6): 21646-21651
Gooley JJ, Lu J, Fischer D and Saper CB (2003)
A broad role for melanopsin in non-visual photoreception
J Neuroscience; 23(18): 7093-7106
Yin Y, Cui Q, Li Y, Irvine N, Fischer D, Harvey AR and Benowitz LI (2003)
Macrophage-derived factors stimulate optic nerve regeneration
J Neuroscience; 23(6): 2284-2293
Thanos S, Fischer D and Heiduschka P (2002)
Evidence for functional regeneration in the visual system of adult rats
Neuro-Ophthalmology; 27 (1-3): 163-176
Fischer D, Heiduschka P and Thanos S (2001)
Lens-injury stimulated axonal regeneration throughout the optic pathway of adult rats
Exp Neurol; 172 (2): 257-272
Tanos S, Fischer D, Pavlidis M, Heiduschka P and Bodeutsch N (2000)
Glio-anatomy assessed by cell-cell interactions and phagocytotic labelling
J Neuroscience Methods; 103 (1): 39-50
Fischer D, Pavlidis M and ThanosS (2000)
Cataractogenic lens injury prevents traumatic ganglion cell death and promotes axonal regeneration both in vivo and in culture
Invest Ophthalmol Vis Sci; 41 (12): 3943-3954
Pavlidis M, Fischer D and Thanos S (2000),
Photoreceptor degeneration in the RCS-rat strain down-regulates ganglion cell ability for dendritic transport and propensity for axonal regeneration
Invest Ophthalmol Vis Sci; 41(8): 2318-2328
Klumpp S, Selke D, Fischer D, Baumann A, Müller F and Thanos S (1998)
Protein phosphatase type-2C isozymes present in vertebrate retinae: purification, characterization and localisation in photoreceptors
J Neuroscience Res; 15 (3): 328-338
Direktor: Univ.-Prof. Dr. Dietmar Fischer
Direktor: Univ.-Prof. Dr. Dietmar Fischer